Monosodium urate (crystals) [1198-77-2]

Catalog number: AG-CR1-3950-M002
Brand: AdipoGen Life Sciences
Packing: 2 mg
Other sizes: 2 x 2 mg
Price: € 78.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Monosodium urate (crystals) [1198-77-2]

Product group: Chemicals
Category: Other
CAS No.: 1198-77-2
Molecular Formula: C5H3N4O3 . Na
Molecular weight: 167.1 . 23.0
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.
Safety information: 
Additional information: 
Synonyms: AG-CR1-3950-M002; AdipoGen Life Sciences; MSU (crystals); Uric acid (crystals)
Gout-associated uric acid crystals activate the NALP3 inflammasome: F. Martinon, et al.; Nature 440, 237 (2006) Read more
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases: M.T. Shio, et al.; PLoS Pathog. 5, e1000559 (2009) Read more
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process: E.J. Giamarellos-Bourboulis, et al.; Ann. Rheum. Dis. 68, 273 (2009) Read more
Monosodium urate crystals in inflammation and immunity: Y. Shi, et al.; Immunol. Rev. 233, 203 (2010) Read more
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality: L. Meng, et al.; PNAS 112, 11007 (2015) Read more