Monosodium urate (ready-to-use) [1198-77-2]

Name: Monosodium urate (ready-to-use) [1198-77-2]
SKU: AG-CR1-3951_A27
Price: 413 EUR
Availability: BackOrder

AG-CR1-3951

Molecular Weight167.1 . 23.0

Product group Chemicals

Overview

Supplier
AdipoGen Life Sciences
Product Name
Monosodium urate (ready-to-use) [1198-77-2]
Delivery Days Customer
10
Certification
Research Use Only
Concentration
20 mg/ml
Hazard Information
Non-hazardous
Molecular Formula
C5H3N4O3 . Na
Molecular Weight
167.1 . 23.0
Scientific Description
Chemical. CAS: 1198-77-2. Formula: C5H3N4O3 . Na. MW: 167.1 . 23.0. NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18. - NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.
SMILES
[Na+].[O-]C1=NC(=O)NC2=C1NC(=O)N2
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Gout-associated uric acid crystals activate the NALP3 inflammasome: F. Martinon, et al.; Nature 440, 237 (2006)
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases: M.T. Shio, et al.; PLoS Pathog. 5, e1000559 (2009)
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process: E.J. Giamarellos-Bourboulis, et al.; Ann. Rheum. Dis. 68, 273 (2009)
Monosodium urate crystals in inflammation and immunity: Y. Shi, et al.; Immunol. Rev. 233, 203 (2010)
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality: L. Meng, et al.; PNAS 112, 11007 (2015)