Nigericin . sodium salt [28643-80-3]

Catalog number: AG-CN2-0020-M005
Brand: AdipoGen Life Sciences
Packing: 5 mg
Other sizes: 25 mg
Price: € 55.00
Expected delivery time: 7 days
Quantity:
Chemical Structure
Chemical Structure...

Product specifications for - Nigericin . sodium salt [28643-80-3]

Overview: 
Product group: Lysates / Extracts
Category: Antibiotics
Source: Isolated from Streptomyces hygroscopicus.
CAS No.: 28643-80-3
Properties: 
Purity: >98%
Molecular Formula: C40H67O11 . Na
Molecular weight: 724.0 . 23.0
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41105330
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator - Chemical. CAS: 28643-80-3. Formula: C40H67O11 . Na. MW: 724.0 . 23.0. Isolated from Streptomyces hygroscopicus. Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator
Safety information: 
ADR klasse: 6; 1
UN Number: UN3462
MSDS: MSDS
Hazard information: H301, H315, H319, H335
Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951) Read more
Potassium Ion-dependent hydrolysis of adenosine triphosphate induced by nigericin in mitochondria: S. Estrada-O, et al.; J. Biol. Chem. 242, 2925 (1967) Read more
Teratogenic effects of nigericin, a carboxylic ionophore: G.C. Vedel-Macrander & R.D. Hood; Teratology 33, 47 (1986) Read more
K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells: L.B. Margolis, et al.; PNAS 86, 6626 (1989) Read more
IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin: D. Perregaux, et al.; J. Immunol. 149, 1294 (1992) Read more
Antitumor effect of k+/h+-antiporter nigericin on human lung-carcinoma grown in in-vivo-like histocultures: B. Baibakov, et al.; Int. J. Oncol. 3, 1127 (1993) Read more
Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodríguez & M. Sitges; Neurochem. Res. 21, 889 (1996) Read more
Activation of interleukin-1beta-converting enzyme by nigericin is independent of apoptosis: N. Watanabe, et al.; Cytokine 10, 645 (1998) Read more
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell Biochem. 85, 83 (2002) Read more
The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43, 15956 (2004) Read more