NU6102 [444722-95-6]

Name: NU6102 [444722-95-6]
SKU: AG-CR1-0020_A27
Price: 57 EUR
Availability: BackOrder

AG-CR1-0020

CAS Number444722-95-6

Product group Chemicals

Estimated Purity>98% (NMR)

Molecular Weight402.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
NU6102 [444722-95-6]
Delivery Days Customer
10
CAS Number
444722-95-6
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous,Warning
Molecular Formula
C18H22N6O3S
Molecular Weight
402.5
Scientific Description
Chemical. CAS: 444722-95-6. Formula: C18H22N6O3S. MW: 402.5. Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 microM), DYRK1A (IC50 = 0.9 microM), PDK1 (IC50 = 0.8 microM) and ROCK-II (IC50 = 0.6 microM). Inhibits cell growth. - Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor [1-3]. 1000-fold more potent than NU2058 [1]. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 microM), DYRK1A (IC50 = 0.9 microM), PDK1 (IC50 = 0.8 microM) and ROCK-II (IC50 = 0.6 microM) [1]. Inhibits cell growth [1].
SMILES
NS(=O)(=O)C1=CC=C(NC2=NC3=C(N=CN3)C(OCC3CCCCC3)=N2)C=C1
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002)
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004)
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)