ONX-0914 [960374-59-8]
HY-13207
CAS Number960374-59-8
Product group Chemicals
Estimated Purity95.03%
Molecular Weight580.67
Overview
- SupplierMedChem Express
- Product NameONX-0914 [960374-59-8]
- Delivery Days Customer9
- CAS Number960374-59-8
- CertificationResearch Use Only
- Estimated Purity95.03%
- Molecular FormulaC31H40N4O7
- Molecular Weight580.67
- Scientific DescriptionONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 microM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.
- SMILESO=C(N[C@@H](C)C(N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(C)OC3)=O)=O)=O)CN4CCOCC4
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200