OTS964 hydrochloride [1338545-07-5]

MedChem Express

OTS964 hydrochloride [1338545-07-5]

10

1338545-07-5

Research Use Only

95.59%

C23H25ClN2O2S

428.97

OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM.

OC1=CC(C)=C2C(C3=C(SC=C3)C(N2)=O)=C1C4=CC=C([C@@H](C)CN(C)C)C=C4.Cl

2°C to 8°C,-20°C,-80°C

12352200