PF-CBP1 hydrochloride [2070014-93-4 [2070014-93-4;]
HY-19999A
Overview
- SupplierMedChem Express
- Product NamePF-CBP1 hydrochloride [2070014-93-4 [2070014-93-4;]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity95.95%
- Molecular FormulaC29H37ClN4O3
- Molecular Weight525.08
- Scientific DescriptionPF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1beta, IL-6 and IFN-beta) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinsons disease, et al.
- SMILESCCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1.Cl[H]
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200