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ProductsBack/PK 11195 [85532-75-8]
Chemical Structure
Chemical Structure
Chemical Structure

PK 11195 [85532-75-8]

Research Use Only
AG-CR1-0008
AdipoGen Life Sciences
CAS Number85532-75-8
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Product group Chemicals
Estimated Purity>98%
Molecular Weight352.9
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    PK 11195 [85532-75-8]
  • Delivery Days Customer
    10
  • CAS Number
    85532-75-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C21H21ClN2O
  • Molecular Weight
    352.9
  • Scientific Description
    Chemical. CAS: 85532-75-8. Formula: C21H21ClN2O. MW: 352.9. Selective peripheral benzodiazepine antagonist. Apoptosis enhancer. Glucose-induced insulin secretion inhibitor. Induces mitochondria cytochrome c release. Anticancer compound. Antiproliferative. Pharmacological tool in autophagy. - Selective peripheral benzodiazepine antagonist [1, 2]. Apoptosis enhancer [3, 5, 8]. Glucose-induced insulin secretion inhibitor [4]. Induces mitochondria cytochrome c release [6]. Anticancer compound [7]. Antiproliferative [9]. Pharmacological tool in autophagy [10].
  • SMILES
    CCC(C)N(C)C(=O)C1=CC2=C(C=CC=C2)C(=N1)C1=CC=CC=C1Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies: G. Le Fur et al.; Life Sci. 33, 449 (1983)
  • Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination: A. Doble et al.; Eur. J. Pharmacol. 119, 153 (1985)
  • PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection: T. Hirsch et al.; Exp. Cell. Res. 241, 426 (1998)
  • Inhibition of glucose-induced insulin secretion by a peripheral-type benzodiazepine receptor ligand (PK11195): D. Pujalte, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 362, 46 (2000)
  • PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor: R.A. Gonzalez-Polo, et al.; Oncogene 24, 7503 (2005)
  • Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition: J. Li, et al.; Eur. J. Pharmacol. 560, 117 (2007)
  • The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells: A.F. Santidrian et al.; Haematologica 92, 1631 (2007)
  • Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195: M. Campanella et al.; Biochem. Pharmacol. 76, 1628 (2008)
  • Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells: S. Mukhopadhyay et al.; Mol. Cell. Biochem. 340, 203 (2010)
  • Ca2+-dependent autophagy is enhanced by the pharmacological agent PK11195: Pharmacological tools in autophagy: A. Gastaldello, et al.; Autophagy 6 607 (2010)