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ProductsBack/PLX4720 [918505-84-7]
Chemical Structure
Chemical Structure
Chemical Structure

PLX4720 [918505-84-7]

Research Use Only
AG-CR1-3577
AdipoGen Life Sciences
CAS Number918505-84-7
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Product group Chemicals
Estimated Purity>99%
Molecular Weight413.8
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    PLX4720 [918505-84-7]
  • Delivery Days Customer
    10
  • CAS Number
    918505-84-7
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C17H14ClF2N3O3S
  • Molecular Weight
    413.8
  • Scientific Description
    Chemical. CAS: 918505-84-7. Formula: C17H14ClF2N3O3S. MW: 413.8. Synthetic. Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines. - Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
  • SMILES
    CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=NC=C(Cl)C=C23)=C1F
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity: J. Tsai, et al.; PNAS 105, 3041(2008)
  • Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival: R.A. Cartlidge, et al.; Pigment Cell Melanoma Res. 21, 534 (2008)
  • Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma: L.M. Packer, et al.; Pigment Cell Melanoma Res. 22, 785 (2009)
  • Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells: P. Salerno, et al.; J. Clin. Endocrinol. Metab. 95, 450 (2010)
  • B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression: C. Nucera, et al.; PNAS 107, 10649 (2010)
  • Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS: C.C. Jiang, et al.; Cell Death Dis. 1, e69 (2010)
  • Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer: C. Nucera, et al.; Oncologist 16, 296 (2011)