Quizartinib [950769-58-1]
HY-13001
CAS Number950769-58-1
Product group Chemicals
Estimated Purity98.83%
Molecular Weight560.67
Overview
- SupplierMedChem Express
- Product NameQuizartinib [950769-58-1]
- Delivery Days Customer10
- CAS Number950769-58-1
- CertificationResearch Use Only
- Estimated Purity98.83%
- Molecular FormulaC29H32N6O4S
- Molecular Weight560.67
- Scientific DescriptionQuizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.
- SMILESO=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200