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ProductsBack/SAG . dihydrochloride (water soluble) [364590-63-6, 912545-86-9]
Chemical Structure
Chemical Structure
Chemical Structure

SAG . dihydrochloride (water soluble) [364590-63-6, 912545-86-9]

Research Use Only
AG-CR1-3585
AdipoGen Life Sciences
Estimated Purity>98% (HPLC).
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Product group Chemicals
Molecular Weight490.1 . 72.9 . 54.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SAG . dihydrochloride (water soluble) [364590-63-6, 912545-86-9]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (HPLC).
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C28H28ClN3OS . 2HCl . 3H2O
  • Molecular Weight
    490.1 . 72.9 . 54.0
  • Scientific Description
    Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable G-Protein-Coupled Receptor (GPCR) smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro. - Chemical. CAS: 912545-86-9 and 364590-63-6 (both free base). Formula: C28H28ClN3OS . 2HCl . 3H2O. MW: 490.1 . 72.9 . 54.0. Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.
  • SMILES
    O.CNC1CCC(CC1)N(CC1=CC(=CC=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: M. Frank-Kamenetsky, et al.; J. Biol. 1, 10 (2002)
  • Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2: W. Chen, et al.; Science 306, 2257 (2004)
  • Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2: A.R. Meloni et al.; Mol. Cell Biol. 26, 7550 (2006)
  • Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells: R.B. Corcoran & M.P. Scott; PNAS 103, 8408 (2006)
  • Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15: C. Masdeu, et al.; BBRC 349, 471 (2006)
  • Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA: F.K. Noubissi, et al.; Cancer Res. 69, 8572 (2009)
  • Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)
  • Converse conformational control of smoothened activity by structurally related small molecules: H. Yang, et al.; J. Biol. Chem. 284, 20876 (2009)
  • Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3: Y. Asoaka, et al.; J. Biol. Chem. 285, 4185 (2010)