SC144 hydrochloride [917497-70-2]
HY-15614A
CAS Number917497-70-2
Product group Chemicals
Estimated Purity98.89%
Molecular Weight358.76
Overview
- SupplierMedChem Express
- Product NameSC144 hydrochloride [917497-70-2]
- Delivery Days Customer10
- CAS Number917497-70-2
- Estimated Purity98.89%
- Molecular FormulaC16H12ClFN6O
- Molecular Weight358.76
- Scientific DescriptionSC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells.
- SMILESO=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200