SIAIS178 [2376047-73-1]
HY-128756
CAS Number2376047-73-1
Product group Chemicals
Estimated Purity98.96%
Molecular Weight1012.68
Overview
- SupplierMedChem Express
- Product NameSIAIS178 [2376047-73-1]
- Delivery Days Customer10
- CAS Number2376047-73-1
- CertificationResearch Use Only
- Estimated Purity98.96%
- Molecular FormulaC50H62ClN11O6S2
- Molecular Weight1012.68
- Scientific DescriptionSIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity.
- SMILESO=C(N1CCN(C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2)CC1)CCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200