Siramesine hydrochloride [224177-60-0]
HY-14221A
CAS Number224177-60-0
Product group Chemicals
Estimated Purity99.05%
Molecular Weight491.04
Overview
- SupplierMedChem Express
- Product NameSiramesine hydrochloride [224177-60-0]
- Delivery Days Customer10
- CAS Number224177-60-0
- CertificationResearch Use Only
- Estimated Purity99.05%
- Molecular FormulaC30H32ClFN2O
- Molecular Weight491.04
- Scientific DescriptionSiramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
- SMILESFC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200