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ProductsBack/SMI-4a [327033-36-3]
Chemical Structure
Chemical Structure
Chemical Structure

SMI-4a [327033-36-3]

Research Use Only
AG-CR1-3503
AdipoGen Life Sciences
CAS Number327033-36-3
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Product group Chemicals
Estimated Purity>95% (NMR)
Molecular Weight273.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SMI-4a [327033-36-3]
  • Delivery Days Customer
    10
  • CAS Number
    327033-36-3
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C11H6F3NO2S
  • Molecular Weight
    273.2
  • Scientific Description
    Chemical. CAS: 327033-36-3. Formula: C11H6F3NO2S. MW: 273.2. Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth. - Selective inhibitor of Pim-1 and Pim-2 protein kinases [1-5]. Inducer of G1 phase cell cycle arrest [1-5]. Inducer of p27Kip1 [1-5]. Inducer of apoptosis through the mitochondrial pathway [1-5]. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway [1-5]. Downregulates c-myc [1-5]. Inhibitor of PRAS40 phosphorylation and mTOR activity [1-5]. Potential anti-cancer compound [2,4,5]. Blocks prostate cancer growth [2,4,5]. Suppressor of cytokines production in lipopolysaccharide (LPS)-induced acute lung injury (ALI)
  • SMILES
    FC(F)(F)C1=CC(\C=C2/SC(=O)NC2=O)=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem. 52, 74 (2009)
  • Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther. 8, 1473 (2009)
  • PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther. 8, 846 (2009)
  • A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.-W. Lin, et al.; Blood 115, 824 (2010)
  • Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; JBC 285, 29128 (2010)