SRT1720 Hydrochloride [1001645-58-4]
ORB322204
CAS Number1001645-58-4
Product group Chemicals
Estimated Purity≥98%
Molecular Weight506.02
Overview
- SupplierBiorbyt
- Product NameSRT1720 Hydrochloride [1001645-58-4]
- Delivery Days Customer16
- CAS Number1001645-58-4
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC25H23N7OS HCl
- Molecular Weight506.02
- Scientific DescriptionSRT1720 is an inhibitor of sirtuin 3 (SIRT3) and activator of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). SRT1720 exhibits nephroprotective, anti-aging, anti-inflammatory, and pro-angiogenic activities. SRT1720 binds the acetyl-Lys site on sirtuins rather than the NAD+ site. In animal models of kidney ischemia/reperfusion injury, SRT1720 improves renal tubular pathology and overall renal function. In animal models fed high fat diets, SRT1720 delays the onset of metabolic diseases and decreases levels of pro-inflammatory cytokines, extending animal lifespan. In animal models of macular degeneration, this compound suppresses activation of NF-kappaB and release of IL-6, IL-8, and MMP-9, decreasing amyloid-beta (Abeta)-induced retinal pigment epithelial barrier disruption. Additionally, SRT1720 increases VEGF secretion and promotes migration and metastasis of breast cancer cells in vitro and in vivo.
- SMILESc1ccc(c(c1)c2cn3c(csc3n2)CN4CCNCC4)NC(=O)c5cnc6ccccc6n5.Cl
- Storage Instruction-20°C
- UNSPSC12352200