Fedratinib [936091-26-8]

MedChem Express

Fedratinib [936091-26-8]

10

936091-26-8

Research Use Only

96.31%

C27H36N6O3S

524.68

Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.

O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O

2°C to 8°C,-20°C,-80°C

12352200