Tubastatin A hydrochloride [1310693-92-5]

BPS Bioscience

Tubastatin A hydrochloride [1310693-92-5]

7

1310693-92-5

Research Use Only

≥98% by HPLC.

C20H21N3O2 HCl

371.9 Da

Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 microM), excluding HDAC8 (IC50 = 0.9 microM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 microM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 microM.

-20°C

12352200