Tubastatin A (Hydrochloride) [1310693-92-5]

Catalog number: HY-13271_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 5 mg
10 mM
50 mg
100 mg
200 mg
Price: € 89.00
Expected delivery time: 10 days
Quantity:

Product specifications for - Tubastatin A (Hydrochloride) [1310693-92-5]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 1310693-92-5
Properties: 
Purity: >98%
Molecular Formula: C20H22ClN3O2
Molecular weight: 371.86
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Tubastatin A Hcl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM, is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). IC50 Value: 15 nM Target: HDAC6 in vitro: Tubastatin A is substantially selective for all 11 HDAC isoforms and maintains over 1000-fold selectivity against all isoforms excluding HDAC8, where it has approximately 57-fold selectivity. In homocysteic acid (HCA) induced neurodegeneration assays, Tubastatin A displays dose-dependent protection against HCA-induced neuronal cell death starting at 5 uM with near complete protection at 10 uM. At 100 ng/mL Tubastatin A increases Foxp3+ T-regulatory cells (Tregs) suppression of T cell proliferation in vitro. Tubastatin A treatment in C2C12 cells would lead to myotube formation impairment when alpha-tubulin is hyperacetylated early in the myogenic process, however, myotube elongation occurs when alpha-tubulin is hyeperacetylated in myotubes. A recent study indicates that Tubastatin A treatment increases cell elasticity as revealed by atomic force microscopy (AFM) tests without exerting drastic changes to the actin microfilament or microtubule networks in mouse ovarian cancer cell lines, MOSE-E and MOSE-L. in vivo: Daily treatment of Tubastatin A at 0.5mg/kg inhibits HDAC6 to promote Tregs suppressive activity in mouse models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully major histocompatibility complex (MHC)-incompatible cardiac allograft rejection.
Safety information: 
MSDS: MSDS