Tyrphostin AG 879 [148741-30-4]

MedChem Express

Tyrphostin AG 879 [148741-30-4]

10

148741-30-4

99.45%

C18H24N2OS

316.46

Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 microM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 microM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.

S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

2°C to 8°C,-20°C,-80°C

12352200