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ProductsBack/WZB117 [1223397-11-2]
Chemical Structure
Chemical Structure
Chemical Structure

WZB117 [1223397-11-2]

Research Use Only
AG-CR1-3694
AdipoGen Life Sciences
CAS Number1223397-11-2
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Product group Chemicals
Estimated Purity>98%
Molecular Weight368.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    WZB117 [1223397-11-2]
  • Delivery Days Customer
    10
  • CAS Number
    1223397-11-2
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C20H13FO6
  • Molecular Weight
    368.3
  • Scientific Description
    Chemical. CAS: 1223397-11-2. Formula: C20H13FO6. MW: 368.3. . GLUT inhibitor (GLUT4 > GLUT1 = GLUT3). Fast-acting irreversible glucose transporter 1 (GLUT1) inhibitor. Binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126, and Trp412. Blocks glucose transport in diverse cancer cells, reducing extracellular lactate and intracellular ATP levels and consequently decreases glycolysis. Anticancer agent in vitro and in vivo. Inhibits cancer cell proliferation, resulting in cell cycle arrest, senescence and necrosis or apoptosis. Inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice. - Glucose transporter GLUT inhibitor (GLUT4 > GLUT1 = GLUT3). Fast-acting irreversible GLUT1 inhibitor. Binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126 and Trp412. Blocks glucose transport in diverse cancer cells, reducing extracellular lactate and intracellular ATP levels and consequently decreases glycolysis. Anticancer agent in vitro and in vivo. Inhibits cancer cell proliferation, resulting in cell cycle arrest, senescence and necrosis or apoptosis. Inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.
  • SMILES
    FC1=C(OC(C2=CC(O)=CC=C2)=O)C(OC(C3=CC=CC(O)=C3)=O)=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo: Y. Liu, et al.; Mol. Cancer Ther. 11, 1672 (2012)
  • A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models: C. Xintaropoulou, et al.; Oncotarget 6, 25677 (2015)
  • Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells: K. Shibuya, et al.; Oncotarget 6, 651 (2015)
  • Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells: A. Koch, et al.; Oncotarget 6, 32748 (2015)
  • WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site: O.A. Ojelabi, et al. J. Biol. Chem. 291, 26762 (2016)
  • Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation: F. Zhao, et al.; Cancer Chemother. Pharmacol. 77, 963 (2016)
  • A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016) (Review)