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ProductsBack/Z-VRPR-FMK [1381885-28-4]
Chemical Structure
Chemical Structure
Chemical Structure

Z-VRPR-FMK [1381885-28-4]

Research Use Only
AG-CP3-0008
AdipoGen Life Sciences
CAS Number1381885-28-4
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Product group Chemicals
Estimated Purity>90% (HPLC)
Molecular Weight676.8 . 114.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Z-VRPR-FMK [1381885-28-4]
  • Delivery Days Customer
    10
  • CAS Number
    1381885-28-4
  • Certification
    Research Use Only
  • Estimated Purity
    >90% (HPLC)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C31H49FN10O6 . C2HF3O2
  • Molecular Weight
    676.8 . 114.0
  • Scientific Description
    Chemical. CAS: 1381885-28-4 (free base). Formula: C31H49FN10O6 . C2HF3O2. MW: 676.8 . 114.0. Synthetic. Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei. - Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
  • SMILES
    OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008)
  • Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma: S. Hailfinger, et al.; PNAS 106, 19947 (2009)
  • Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2: S.I. Gringhuis, et al.; PLoS Pathogens 7, e1001259 (2011)
  • Crystal structure of a Trypanosoma brucei metacaspase: K. McLuskey, et al.; PNAS 109, 7469 (2012)
  • MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)
  • The protease activity of the paracaspase MALT1 is controlled by monoubiquitination: C. Pelzer, et al.; J. Immunol. 14, 337 (2012)