ACE2 peptide (788-805)
GTX15352
ApplicationsNeutralisation/Blocking, Other Application
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameACE2 peptide (788-805)
- Delivery Days Customer10
- ApplicationsNeutralisation/Blocking, Other Application
- CertificationResearch Use Only
- Concentration0.20 mg/ml
- Scientific DescriptionAngiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
- Storage Instruction-20°C
- UNSPSC12352202
References
- Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Yamazato M et al., 2007 Apr, HypertensionRead more