GN44028 [1421448-26-1]

MedChem Express

GN44028 [1421448-26-1]

10

1421448-26-1

Research Use Only

0.99

C18H15N3O2

305.33

GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1alpha inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1alpha transcriptional activity without suppressing HIF-1alpha mRNA expression, HIF-1alpha protein accumulation, or HIF-1alpha/HIF-1beta heterodimerization. GN44028 can be used in the research of cancers.

C1(NC2=CC=C(OCCO3)C3=C2)=NNC4=C1CC5=CC=CC=C45

2°C to 8°C,-20°C,-80°C

12352200