Mutant IDH1-IN-4 [1416270-18-2]

MedChem Express

Mutant IDH1-IN-4 [1416270-18-2]

10

1416270-18-2

0.99

C25H34N4O3

438.56

Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 microM for mutant IDH1 in R132H, HT1080 and U87R132H cells.

N#CC1=C(N2C[C@@H](C3CC3)N(C(CCOC)=O)CC2)N=C(C4CC4)C5=C1CC(C)(C)OC5

2°C to 8°C,-20°C,-80°C

12352200