A-381393 [726174-00-1]

MedChem Express

A-381393 [726174-00-1]

10

726174-00-1

Research Use Only

99.9%

C20H24N4

320.43

A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM).

CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3

2°C to 8°C,-20°C,-80°C

12352200