B7-H6 (human):Fc (mouse) (rec.)

Catalog number: CHI-HF-211B7H6-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 350.00
Expected delivery time: 7 days
Quantity:

Product specifications for - B7-H6 (human):Fc (mouse) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: HEK 293 cells
Properties: 
Purity: >98% (SDS-PAGE)
Molecular weight: 80 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
Swiss prot ID: NP_001189368.1
Additional information: 
Synonyms: CHI-HF-211B7H6-C100; Chimerigen Laboratories