CD137 (human) (rec.) (His)

Catalog number: CHI-HR-200CD137-C025
Brand: Chimerigen Laboratories
Packing: 25 ug
Price: € 290.00
Expected delivery time: 7 days

Product specifications for - CD137 (human) (rec.) (His)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: E. coli
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
Swiss prot ID: AAH06196.1
Additional information: 
Synonyms: CHI-HR-200CD137-C025; Chimerigen Laboratories; 4-1BB / CD137; TNFRSF9; ILA; CDw137; CD137; 4-1BB; tumor necrosis factor receptor superfamily member 9; receptor protein 4-1BB; interleukin-activated receptor, homolog of mouse Ly63; induced by lymphocyte activation (ILA); homolog of mouse 4-1BB; T-cell antigen ILA; T-cell antigen 4-1BB homolog; T cell antigen ILA; CD137 antigen; 4-1BB ligand receptor; tumor necrosis factor receptor superfamily, member 9