CD40L (mouse) (multimeric) (rec.)

Catalog number: AG-40B-0020-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: 3 x 10 ug
Price: € 300.00
Expected delivery time: 7 days

Product specifications for - CD40L (mouse) (multimeric) (rec.)

Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Source: CHO cells
Purity: >95% (SDS-PAGE)
Molecular weight: 35-40 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.1mg/ml after reconstitution.
Form supplied: Lyophilized. Contains PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: MultimericCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Swiss prot ID: P27548
Safety information: 
Additional information: 
Synonyms: AG-40B-0020-C010; AdipoGen Life Sciences; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003) Read more
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes: G. Guarda, et al.; Nature 460, 269 (2009) Read more