CD80 (human):Fc (mouse) (rec.)

Catalog number: CHI-HF-211CD80-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 350.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD80 (human):Fc (mouse) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Properties: 
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD80 (B7-1) and CD86 (B7-2) together with their receptors CD28 and CTLA-4 constitute one of the dominant costimulatory pathways that regulate T cell and B cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon-gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily. It has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.
Swiss prot ID: NP_005182.1
Additional information: 
Synonyms: CHI-HF-211CD80-C100; Chimerigen Laboratories; CD80; LAB7; CD28LG1; CD28LG; BB1; B7.1; B7-1; B7; costimulatory molecule variant IgV-CD80; costimulatory factor CD80; activation B7-1 antigen; T-lymphocyte activation antigen CD80; CTLA-4 counter-receptor B7.1; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); B-lymphocyte activation antigen B7; CD80 molecule