IL-21 (mouse):Fc (mouse) (rec.)

Catalog number: CHI-MF-11021-C050
Brand: Chimerigen Laboratories
Packing: 50 ug
Price: € 360.00
Expected delivery time: 7 days
Quantity:

Product specifications for - IL-21 (mouse):Fc (mouse) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Species: Mouse
Source: HEK 293 cells
Properties: 
Purity: >98% (SDS-PAGE)
Molecular weight: 45 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naïve T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.
Swiss prot ID: NP_068554.1
Additional information: 
Synonyms: CHI-MF-11021-C050; Chimerigen Laboratories