Rat NAP-2 protein

Biorbyt

Rat NAP-2 protein

16

HPLC, SDS-PAGE

Research Use Only

>97%

Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP)which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELRdomain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and tochemoattract and activate neutrophils. Although CTAP-III, C-TG and PBP represent amino-terminal extended variants of NAP-2and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown thatthe additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2and may account for lack of NAP-2 activity.

E.coli

2°C to 8°C,-20°C

12352202