Tat-NR2B9c [500992-11-0]
HY-P0117
CAS Number500992-11-0
Product group Chemicals
Estimated Purity99.56%
Molecular Weight2518.88
Overview
- SupplierMedChem Express
- Product NameTat-NR2B9c [500992-11-0]
- Delivery Days Customer10
- CAS Number500992-11-0
- Estimated Purity99.56%
- Molecular FormulaC105H188N42O30
- Molecular Weight2518.88
- Scientific DescriptionTat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 microM and 8 microM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.
- SMILES[YGRKKRRQRRRKLSSIESDV]
- Storage Instruction-20°C,-80°C
- UNSPSC12352200