TNF-alpha, Soluble (human) (rec.)

Catalog number: AG-40B-0006-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: 50 ug
3 x 50 ug
Price: € 80.00
Expected delivery time: 7 days
Quantity:

Product specifications for - TNF-alpha, Soluble (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Species: Human, Mouse
Target: TNF
Target description: tumor necrosis factor
Source: E.coli
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~17kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized. Contains PBS.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: Protein. A FLAG®-tag is fused at the N-terminus of human TNF-alpha (aa 85-223). Source: E. coli. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse TNF-R1. Purity: >95% (SDS-PAGE). Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha can be used. - Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha can be used.
Gene ID: 7124
Swiss prot ID: P01375
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: APC1 protein; cachectin; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNFA; TNF-alpha; TNFSF2; TNLG1F; tumor necrosis factor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha