VISTA (mouse):COMP (mouse) (rec.) (His)

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Product specifications for - VISTA (mouse):COMP (mouse) (rec.) (His)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Species:	Mouse
Target:	Vsir
Target description:	V-set immunoregulatory receptor

Properties:
Purity:	>95% (SDS-PAGE)
Molecular weight:	~35-40kDa (SDS-PAGE) and >250kDa (Size Exclusion Chromatography (SEC))
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Concentration:	1 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Mouse VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (mouse):COMP (mouse) (with the extracellular domain of VISTA (mouse) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells. - Protein. The extracellular domain of mouse VISTA (aa 33-191) is fused at the C-terminus to the domain of the mouse cartilage oligomeric matrix protein (COMP) (aa 28-72) and a His Tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). Mouse VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (mouse):COMP (mouse) (with the extracellular domain of VISTA (mouse) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells.
Gene ID:	74048
Swiss prot ID:	Q9D659

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-40B-0181-C050; AdipoGen Life Sciences; 4632428N05Rik; Dies1; differentiation of ESCs 1; PD-1H; platelet receptor Gi24; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation

VISTA.COMP - an engineered checkpoint receptor agonist that potently suppresses T cell-mediated immune responses: A. Prodeus, et al.; JCI Insight 2, e94308 (2017)

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Product specifications for - VISTA (mouse):COMP (mouse) (rec.) (His)