Z-Leu-Leu-Glu-AMC [Z-LLE-AMC] [348086-66-8]

Catalog number: SBB-PS0006-M002
Brand: South Bay Bio
Packing: 2 mg
Price: € 141.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Z-Leu-Leu-Glu-AMC [Z-LLE-AMC] [348086-66-8]

Product group: Proteins / Signaling Molecule
Category: Peptide
Source: Synthetic.
CAS No.: 348086-66-8
Purity: >99%
Molecular Formula: C35H44N4O9
Molecular weight: 664.8
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Form supplied: Lyophilized powder.
Storage instructions: +4°C tot -20°C
Scientific information: 
Scientific info: Z-LLE-AMC is a fluorogenic peptide substrate for measuring caspase-like activity of the proteasome. Hydrolysis of this substrate by the beta1-subunit of the 20S proteasome is monitored by observing fluorescence at an Excitation wavelength of 345nm and Emission at 445nm. This substrate is specific to the constitutive proteasome and is not hydrolyzed efficiently by the immunoproteasome. 20S proteasome enzyme requires activation with 0.035% SDS in the assay buffer.
Additional information: 
Synonyms: SBB-PS0006-M002; South Bay Bio
5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor: T.L. Chang, et al.; Planta Med. 76, 987 (2010) Read more
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit: J. Blackburn, et al.; Biochem. J. 430, 461 (2010) Read more