Hoechst 34580 tetrahydrochloride

Catalog number: HY-15560B_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 5 mg
10 mM
10 mg
50 mg
Price: € 426.00
Expected delivery time: 10 days

Product specifications for - Hoechst 34580 tetrahydrochloride

Product group: Technique Specific Products
Category: Immunohistochemistry
Subcategory: DAPI / Hoechst / Hematoxylin
Molecular Formula: C27H33Cl4N7
Molecular weight: 597.40982
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116134
Scientific information: 
Scientific info: Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei. IC50 & Target: Amyloid-beta[1] In Vitro: Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86+/-0.05 uM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer s disease by inhibiting Abeta formation. 50 uM Abeta42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 uM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Abeta42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Abeta42 concentration which gave 0.86+/-0.05 uM for Hoechst 34580[1].
Safety information: 
Additional information: 
Synonyms: HY-15560B