Precise Adrenal Function Assessment with Human CBG ELISA

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Why do we need to measure CBG?

Corticosteroid-Binding Globulin (CBG) is the liver produced protein responsible for binding cortisol, the key hormone involved in processes such as stress response, metabolism, and immune regulation. While total cortisol measurement is widely used in both clinical and research settings, it does not always provide the complete picture. Only free cortisol is biologically active, while the majority is bound to CBG (approximately 80–90%) or to albumin (approximately 5–10%). Measuring CBG is therefore essential for accurate cortisol interpretation, particularly in conditions where CBG levels are altered, such as pregnancy, stress, estrogen therapy, or liver disease.

Why use BioVendor’s Human CBG ELISA?

BioVendor’s Human CBG ELISA is a CE IVD certified diagnostic tool developed to address this need. It provides laboratories with a reliable, cost-effective, and radiation-free alternative to traditional RIA methods. With optimized component volumes, the kit is suitable for both manual and automated workflows. The excellent correlation between RIA and ELISA methods is demonstrated in the graph below:

Key advantages of the Human CBG ELISA include:

• CE IVD certification ensuring compliance with diagnostic standards
• Quality controls included in the kit
• Fully validated for serum and plasma samples
• Automation-friendly format with optimized reagent volumes
• Non-radioactive, cost-effective alternative to RIA methods
• Effective preselection of samples for mass spectrometry (LC–MS/MS)
• No need for 24-hour urine collection

By enabling reliable measurement of CBG, this assay supports clinicians and researchers in refining cortisol interpretation, reducing the risk of misdiagnosis, and improving patient outcomes. For laboratories seeking to replace radioactive assays with a modern, user-friendly solution, the Human CBG ELISA represents a unique and powerful tool.

Learn more about CBG as a biomarker and discover how BioVendor’s Human CBG ELISA can enhance your diagnostic capabilities in our detailed product flyer.