BioVendor: Precise measurement of cartilage degradation in osteoarthritis with the Human Cartilage Oligomeric Matrix Protein (COMP) ELISA, detecting a key biomarker of cartilage turnover and joint disease progression.
Cartilage Oligomeric Matrix Protein (COMP) is a structural protein that plays a role in maintaining cartilage integrity. It stabilizes the collagen network and ensures proper organization of the extracellular matrix, helping cartilage withstand mechanical stress.
When cartilage is damaged or begins to degrade — for example, in osteoarthritis (OA), early rheumatoid arthritis (RA), or as a result of mechanical overload — COMP is released from the tissue into surrounding fluids. Elevated COMP concentrations therefore reflect ongoing cartilage turnover and degeneration.
This makes COMP a valuable biomarker for joint disease assessment. Measuring its concentration allows clinicians or researchers to monitor disease activity, evaluate the progression of cartilage damage, or assess treatment efficacy in both preclinical and clinical studies.
Serum or Synovial Fluid?
Choosing the right sample type is crucial. While COMP can be detected in both serum and synovial fluid, its dynamics differ significantly. According to exploratory analysis from the KANON trial, COMP concentrations in synovial fluid were twofold higher within six weeks after anterior cruciate ligament (ACL) injury – a condition associated with early osteoarthritis – and remained elevated for up to five years. In contrast, serum COMP levels did not differ from reference values at any time point. These findings highlight the importance of sample selection and interpretation when studying cartilage biomarkers.
The Human COMP ELISA from BioVendor represents a reliable and high-quality solution for precise quantification of COMP. As a CE IVD-certified assay, it meets the highest standards of analytical performance and reproducibility. The kit has been validated for both serum and synovial fluid samples, ensuring flexibility in research and diagnostic applications related to cartilage metabolism, osteoarthritis progression, and joint tissue regeneration.
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