Synthetic Nanodisc Solution for Transmembrane Protein Research
OriGene’s portfolio of over 700 Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters, offers a powerful solution for advancing membrane protein research and drug discovery.
OriGene provides an innovative solution for transmembrane protein research using a Synthetic Nanodisc platform that preserves native structure, improves stability, and enables functional studies of difficult membrane proteins.
They offer more than 700 full-length multipass transmembrane targets in synthetic nanodisc format, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters, offers a powerful solution for advancing membrane protein research and drug discovery.
What are Synthetic Nanodiscs and why do they matter?
Synthetic Nanodiscs are nanoscale, disc-shaped membranous particles that encapsulate full-length transmembrane proteins directly from cell membranes using specialized polymers. Unlike traditional membrane scaffold protein (MSP) nanodiscs, synthetic Nanodiscs are formed without the use external scaffold proteins and are detergent-free membrane protein, which helps preserve the native conformation and biological activity of target proteins.
This unique approach enables researchers to work with biologically active membrane proteins in aqueous environments, overcoming many hurdles that have historically hindered transmembrane protein studies.
Key Benefit
Preserves native structure and function of full-length multipass membrane proteins
Produces highly purified, water-soluble, and stable proteins
Detergent-free workflow reduces assay interference and artifacts
Maintains high biological activity for functional studies
Lyophilized for long-term storage and easy reconstitution
Applications
Improved antigen presentation for ELISA and immunoassays
Reliable binding kinetics for SPR affinity analysis
Native target display for phage screening and discovery
Enhanced cell-based assays, including CAR-T screening
Supports structural studies such as crystallography and cryo-EM
Featured Transmembrane Proteins
Human SLC7A11 (12-Pass Transmembrane Protein) Catalog #:TP721420
Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE
Flagged tagged SLC7A11-Nanodisc can bind anti-Flag mAb. EC50 of 4.101ng/ml for SLC7A11-Nanodisc
Human CLDN18.2 (4-pass Transmembrane Protein) Catalog #:TP721388
Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE
Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb. EC50 of 593.6ng/ml for CLDN18.2-Nanodisc
Human CLDN18.2-Nanodisc can bind anti-CLDN18.2 antibody with an affinity constant of 1.619 nM as determined in a SPR assay.
Human MDR-1 (12-Pass Transmembrane Protein) Catalog #: TP721401
Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE
MDR-1-Nanodisc can bind anti-Flag monoclonal antibody. EC50 of 6.883ng/ml for MDR-1-Nanodisc
Human GPRC5D (7-Pass Transmembrane Protein) Catalog #: TP721385
Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE
GPRC5D-Nanodisc can bind anti-GPRC5D mAb. EC50 of 32.86ng/ml for GPRC5D-Nanodisc
Human CD63 (4-Pass Transmembrane Protein) Catalog #: TP721402
Highly active CD63 nanodisc protein
Highly stable CD63 nanodisc protein
Highly stable CD63 nanodisc protein as shown by accelerated test on lyophilized protein
For more information about OriGene’s solutions to Transmembrane Proteins, please contact one of our account managers.
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