QuidelOrtho SPG: The complement system is recognised as a key player in a wide variety of fields. This article explores why it’s so fascinating.
The complement system, a central component of innate immunity, has long been known as a first-line defense against infection. It consists of more than 50 circulating and membrane-bound proteins that interact in tightly regulated activation cascades. Traditionally understood as a mechanism for pathogen clearance and inflammation induction, the complement system is now increasingly recognized as a pivotal player in numerous biological process and disease states.
Dysregulation of the complement system is now implicated in a wide array of both localized and systemic diseases, spanning fields such as:
In response to its expanding clinical relevance, more than 10 complement inhibitors are currently approved, with many more in clinical trials and development. Additionally, complement-dependent cytotoxicity–hijacking therapies are gaining clinical interest. Complement biomarkers are also being explored as prognostic and predictive indicators, highlighting the system’s value not only in therapy but also in precision medicine.
QuidelOrtho SPG offers a comprehensive portfolio for complement system assessment. Our IVD and CE-marked ELISA kits provide accurate quantification of complement proteins, enabling complete evaluation across all pathways of activation. We also offer first-in-class complement multiplex assays, antibodies, proteins and sera-based reagents such as depleted sera, normal human serum and cobra venom factor. These tools support a wide spectrum of research needs across academia, pharmaceutical development and more. These products have been validated by the complement research community across diverse applications and sample types in thousands of peer-reviewed literature publications.
The complement system is essential not only to innate immunity but to understanding and addressing a wide range of diseases. QuidelOrtho is your trusted partner for advancing complement system research.
| CAT # | Description | Analytes |
|---|---|---|
| A900 | Complement Multiplex – Panel 1 | Ba, Bb, C3a, C4a, C5a, sC5b-9, FH, FI |
| A901 | Complement Multiplex – Panel 1 Focused | Bb, C3a, C4a, C5a, sC5b-9 |
| A916 | Complement Multiplex – Panel 2 | C1q, C2, C3, C4, C5, FD, FP |
| A917 | Complement Multiplex – Panel 2 Focused | C1q, C3, C4, C5 |
| CAT # | Description | Analytes |
|---|---|---|
| A903 | Custom 3-plex | Compatibility A limited selection of analytes are not compatible for Panel 1: • C3a is not compatible with C3d • C4a is not compatible with C4d |
| A904 | Custom 4-plex | |
| A905 | Custom 5-plex | |
| A906 | Custom 6-plex | |
| A907 | Custom 7-plex | |
| A908 | Custom 8-plex | |
| A909 | Custom 9-plex | |
| A910 | Custom 10-plex |
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