MS Validated Antibodies

Many antibody suppliers provide very little information and images of how an antibody stains. References are often limited to a positive and negative control on their website. When pathologists and researchers use these antibodies, they don’t know the full staining behavior of an antibody because they often don’t have the time or access to enough different tissues to perform in-house validation of the antibody. This can cause serious problems because researchers cannot know if they can trust the antibody and the data they have generated in their studies.

MS Validated Antibodies (MSVA) is dedicated to providing optimal monoclonal antibodies for immunohistochemistry and to providing users with unique product documentation that allows them to know as much as possible about their antibodies. Key features of the MSVA package include:

• Highly stringent criteria for product selection: Only 175 out of the first 7000 antibodies evaluated were selected for the MSVA portfolio.
• Unique product documentation including images of more than 60 different normal tissues and more than 20 tumor images per antibody.
• All MSVA antibodies are validated for immunohistochemistry according to the IWGAV (International Working Group of Antibody Validation) validation guidelines on 76 different normal tissues and >1,000 tumors.
• Suggested protocols for manual staining and autostainers (Dako, Leica, Ventana).
• Published data on the performance characteristics of our antibodies are compiled on the MSVA homepage (where available).
• Extensive educational content is provided for each antibody including links to other relevant sites.

Extensively validated, high-quality antibodies are key to successful experiments. Optimal antibodies are especially critical for multiplex fluorescence immunohistochemistry where even a single cross-reactive antibody can ruin an entire experiment.

The majority are rabbit recombinant antibodies. These have the advantage of being fully reproducible, as they are not produced by potentially unstable hybridoma cells, but “in the lab” based on the known DNA sequence of the antibody chains.

For a quote request or product information, please contact us using quotes@bio-connect.nl.