AmoyDx® Super-ARMS ESR1 PCR Kit
AmoyDx® Super-ARMS ESR1 PCR Kit is a highly sensitive real-time PCR assay for detecting ESR1 mutations from plasma cfDNA (liquid biopsy).
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Find products for your researchESR1 mutations are a key mechanism of acquired resistance in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer, impacting patient prognosis and guiding treatment decisions for second-line endocrine therapy. With a detection sensitivity as low as 0.2% mutant allele frequency, this kit enables in-house laboratories to accurately identify 29 ESR1 mutations, helping clinicians monitor endocrine therapy resistance and optimize treatment strategies.
Interested in AmoyDx® Super-ARMS ESR1 PCR Kit?
Please contact one of our account managers for more information on the AmoyDx® Super-ARMS ESR1 PCR Kit, or request a quote directly. Our team is happy to assist you with any inquiries and provide further details.
Clinical Utility
- Identify Resistance Mechanisms: ESR1 mutations are present in ~20–40% of HR+/HER2- metastatic breast cancer patients who progress on aromatase inhibitors. Detecting these mutations informs treatment adaptation to overcome endocrine resistance.
- Guide Treatment Selection: ESR1 mutation-positive patients benefit from targeted therapies such as elacestrant, which has been shown to significantly reduce disease progression risk compared to standard treatments.
- Improve Prognostic Assessment: Carrying ESR1 mutations is associated with distinct prognostic characteristics, providing important information for patient stratification and supporting personalized care decisions.
Product Features
- Intended Use: Reseach Use Only
- Technology: Super-ARMS real-time PCR
- Sample Type: Liquid biopsy (cfDNA from plasma)
- Sensitivity: Detects mutant allele frequency as low as 0.2%
- Coverage: 29 ESR1 mutations
- Format: Pre-loaded, ready-to-use reagent tubes
- Automated Analysis: ARAS software for streamlined result interpretation
Why Choose AmoyDx® Super-ARMS ESR1 PCR Kit?
High Sensitivity Aligned with Clinical Conditions: AmoyDx’s performance is validated under clinically relevant sample conditions (~1500 copies), ensuring reliable results for real-world samples.
Rapid Turnaround, In-House Control: By enabling local testing, laboratories can avoid the long turnaround times typical of send-out testing; delivering faster, actionable results.
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Please contact one of our account managers for more information on the AmoyDx® Super-ARMS ESR1 PCR Kit, or request a quote directly. Our team is happy to assist you with any inquiries and provide further details.
Download the product flyer here.
Although the AmoyDx® Super-ARMS ESR1 PCR Kit is for Research Use Only (RUO), the EMA approval for elacestrant (ORSERDU™) states that where a CE-IVD assay is not available, a validated assay may be used to guide treatment decisions. You can refer to the EMA product information here: https://www.ema.europa.eu/en/documents/product-information/orserdu-epar-product-information_en.pdf
