Metatissue

3D Cell Culture | Human-Derived | Xeno-Free | NAMs | Bioinks | Tissue Engineering | Drug Discovery | Cancer Research | Biomaterials

Metatissue® is a biotechnology company founded in 2018, originating from the COMPASS Research Group at CICECO, University of Aveiro. The company is dedicated to the development of advanced 3D cell culture platforms using human-derived proteins, enabling more predictive and translatable in vitro models for biomedical research and drug development.

Major Product Lines

Metatissue® offers a portfolio of advanced biomaterials designed for 3D cell culture and related applications:

  • hPLMA Hydrogel – Photopolymerizable human platelet lysate-based hydrogels with tunable mechanical properties
  • hPLMA Sponge – Ready-to-use porous scaffolds for enhanced cell growth and migration
  • hPLMA Easy – Pre-formulated hydrogel systems with integrated photoinitiator for simplified workflows

These product lines are designed to replicate human physiological conditions more accurately than traditional matrices, supporting improved experimental outcomes

Unique Selling Points (USPs)

  • Human-derived, xeno-free biomaterials for physiologically relevant models
  • Designed to improve predictive power of preclinical studies
  • Enables reduction or replacement of animal testing
  • Tunable hydrogels with controllable stiffness and gelation time
  • High reproducibility across batches and applications
  • Ready-to-use and easy-to-handle product formats
  • Strong foundation in academic research and validation
  • Cost-effective solutions that reduce failed clinical candidates
  • Facilitates seamless adoption across established research pipeline
  • Designed for interoperable integration into standardized workflows

Specialising in the design and manufacturing of xeno-free hydrogels, bioactive scaffolds, and bioinks, Metatissue® provides solutions that closely mimic physiological microenvironments. These platforms support a wide range of applications, including disease modelling, drug discovery, tissue engineering, and personalized medicine.

Metatissue®’s technology addresses one of the major challenges in preclinical research: the lack of reliable human-relevant models. By offering human-based biomaterials derived from ethically sourced proteins, the company enables researchers to generate more accurate data, ultimately improving the success rate of clinical trials.

A key advantage of Metatissue’s platforms is their potential to significantly reduce, or even replace, the use of animal models in pre-clinical screening. This not only accelerates research timelines and reduces costs but also supports ethical research practices and ultimately also aids regulatory overview.

Documents

Custom services

Metatissue® provides tailored solutions to meet specific research and development needs:

  • Development of human-derived hydrogels, sponges, and bioinks
  • Product optimisation for specific cell types or applications
  • Collaboration on disease models and drug screening platforms
  • Support in material characterization and validation

Joint R&D projects with academic and industry partners.

More about Metatissue

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