MagCore Giga: 8 mL Extraction in One Cartridge

High-yield extraction for demanding workflows

RBC Bioscience introduces MagCore® Giga, a new automated large-volume nucleic acid extraction instrument designed for laboratories that need higher sample input, stronger nucleic acid yield, and a more efficient workflow for today’s molecular testing demands.

As clinical diagnostics and life science research continue to advance, sample volume has become a critical factor in sensitive downstream applications. Liquid biopsy, early cancer screening, minimal residual disease monitoring, NIPT, biobanking, and NGS-based testing all depend on the ability to recover high-quality DNA or RNA from biological samples where target molecules may be present at very low concentrations. For plasma cfDNA workflows, especially in oncology and early detection research, larger input volumes can support better recovery of low-abundance nucleic acids.

One cartridge for a full 8 mL run

MagCore Giga was designed to meet this growing market need with a true large-volume automated extraction workflow. One of its strongest advantages is its unique 1 cartridge for 1 full 8 mL extraction design. Unlike workflows that require large samples to be split across multiple cartridges or processed with additional manual pooling steps, MagCore Giga enables laboratories to process one 8 mL sample in one dedicated cartridge. This helps reduce hands-on handling, minimize sample loss, simplify operation, and support more consistent automated DNA/RNA extraction.

Flexible runs with minimal reagent waste

The system also brings important efficiency benefits to routine laboratory operation. MagCore Giga can process 1 to 8 samples per batch, allowing users to run only the number of samples required. Because each sample uses its own cartridge, laboratories do not need to waste reagents on unused positions during partial runs. This flexible format supports cost-conscious reagent use, practical daily operation, and walkaway automation for both low-volume and specialized high-value testing.

Designed for large-volume performance

Built on RBC Bioscience’s cellulose-coated magnetic bead technology, MagCore Giga supports automated nucleic acid purification from large-volume whole blood and plasma samples. The instrument features a 20 mL sample tube, large-volume heating capacity, pre-filled reagent cartridges, an exclusive 5 mL pipette tip, barcode scanning, UV decontamination, a 7-inch full-color touch screen, USB-upgradeable programs, and LIMS-compatible traceability.

For biobanking, liquid biopsy, and oncology

For biobanking laboratories, MagCore Giga supports high-yield genomic DNA and RNA extraction from whole blood. For liquid biopsy and oncology research, it enables large-volume plasma cfDNA extraction for sensitive downstream applications such as next-generation sequencing, early cancer screening studies, NIPT, and MRD monitoring.

MagCore Giga expands the MagCore product family by addressing a clear need in the market: automated extraction from ultra-large sample volumes without sacrificing workflow convenience. For whole blood applications, the system supports high-yield genomic DNA and RNA extraction, making it suitable for biobanking and large-scale sample storage programs. For plasma applications, it enables large-volume cfDNA extraction for sensitive downstream applications such as NGS-based oncology workflows and NIPT.

Big-volume power in a compact system

With MagCore Giga, RBC Bioscience delivers a compelling new solution for the large-volume nucleic acid extraction market: 8 mL input, one cartridge, no unnecessary reagent waste, flexible 1-8 sample processing, walkaway automation, and reliable DNA/RNA purification in a compact bench-top system.

Available via Bio-Connect

MagCore Giga is available through the Bio-Connect webshop, enabling clinical, research, and biobanking laboratories to easily adopt this large-volume automated extraction platform into their existing workflows. For more information, technical support, or a quotation, please contact your Bio-Connect account manager or reach out via our webshop contact page.