14 June 2024

Bio-Connect is up to date on Paragon’s key products

Last week, our Account Managers and Technical Support colleagues received informative training from our supplier, Paragon Genomics, on their product portfolio.


The training focused on Paragon’s CleanPlex® technology for targeted DNA and RNA sequencing (NGS). CleanPlex® is an ultra-scalable and ultra-sensitive NGS amplicon sequencing technology. It features a highly advanced proprietary multiplex PCR primer design algorithm, exceptionally uniform multiplex PCR amplification chemistry, and an innovative, patented background cleanup chemistry. Together, these components enable CleanPlex ready-to-use and custom NGS panels to surpass the limits of traditional amplicon-based and hybrid capture-based target enrichment technologies.

Feature Highlights:

  • Super high amplification uniformity and super low PCR background noise (more accurate variant calling or lower sequencing costs)
  • Single-tube and 3 hour workflow with minimal hands-on time (easy automation)
  • Compatible with difficult samples (degraded FFPE DNA, FFPE RNA, cfDNA, cfRNA) and major sequencing platforms (Illumina, Ion Torrent, Genapsys, MGI DNBSeq)
  • Extreme sensitivity (down to single cell level direct amplification*)
  • Excellent scalability of panel size from a few to over 20,000 amplicons in a single multiplex PCR pool
  • Detection of and analysis for single nucleotide variants (SNVs), small insertions and deletions (indels), copy number variations (CNVs), gene fusions / splice variants, gene expression levels, tumor mutational burden (TMB), microsatellite instability (MSI), internal tandem duplication (ITD), etc.

All in all, the training was very helpful for us. We are now equipped with the most up-to-date knowledge. Please do not hesitate to contact us. We are very happy to assist you with your inquiries.

Please also take a look at Paragon Genomics portfolio. For more information about Paragon Genomics and their Sequencing Technology, visit their supplier page.

Bio-Connect is up to date on Paragon’s key products

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