Cancer stem cells
Powerful tools for in vivo CSC drug discovery and basic cancer research
Easy single-cell passage of human ES and iPS cells without rock inhibitors
Biolaminin 521 LN (LN521) is a full-length, human, recombinant laminin 521 cell culture substrate. It provides an optimal environment for feeder-free culture of human PSCs, MSCs and most anchoragedependent progenitor cell types under completely chemically defined, animal component-free conditions. LN521 renders a single-cell passage hPSC culture system that is medium independent and offers a weekend-free protocol. Importantly, the cells behave predictably, are homogenously pluripotent and karyotypically stable.
Laminins are glycoproteins in the basement membranes surrounding virtually all cells. Laminins bind to cell surface receptors activating cell signaling cascades, leading to more functional and authentic cells.
Laminin 521 is a key basement membrane protein of the natural stem cell niche and is expressed and secreted by hPSCs in the inner cell mass of the embryo. LN521 therefore supports reliable expansion of hESCs and hiPSCs and subsequent cell lineage specification. It also has a positive effect on stabilizing and homogenizing the pluripotent gene expression profiles between different hESC lines.
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