19 May 2022

IL17: A driver of autoimmune disease and inflammation

Sino Biological has developed bioactive recombinant IL17 cytokines from various species, such as human, mouse, cynomolgus, rabbit, marmoset, rhesus, and canine.


Interleukin-17 (IL17/IL17A) is a pro-inflammatory cytokine produced by T helper 17 (Th17) cells. Because of its crucial roles in immune regulation, IL17 is now a target for an array of therapeutic monoclonal antibodies and inhibitors to treat various inflammatory diseases and cancer.

IL17 belongs to a distinct cytokine family with five additional members: IL17B, IL17C, IL17D, IL17E/IL25, and IL17F. IL17 shares the most sequence homology with IL17F. IL17 and IL17F form homodimers and heterodimers (IL17A & IL17F) to signal through the receptor complex composed of the subunits of IL17RA and IL17RC. Both IL17 and IL17F are major contributors in recruiting neutrophils to sites of inflammation. The IL17 and IL17F signaling can induce the production of cytokines (IL-1β, TNFα, G-CSF, IL-6, etc.), chemokines (MCP-1/CCL2, CXCL1, CXCL2, CCL20, etc.), inflammatory effectors, and antimicrobial proteins. The IL17RA subunit is used by at least two other ligands, IL17C and IL17E. Other members of the IL17 Receptor family include IL17RB, IL17RC, IL17RD, and IL17RE. Sino Biological has developed a panel of high-quality recombinant IL17 family cytokines and receptor proteins as well as antibodies to support the study of this cytokine family.

Recombinant IL17 cytokines

Sino Biological has developed bioactive recombinant IL17 cytokines from various species, such as human, mouse, cynomolgus, rabbit, marmoset, rhesus, and canine.

Recommended recombinant IL-17A cytokines

Cat. No.MoleculeSpeciesTagExpressed hostActivity
12047-H07BIL17AHumanN-HisInsect CellsActive
12047-H07YIL17AHumanN-HisYeast CellsActive
12047-HNAEIL17AHumanNativeE. coli CellsActive
12047-HNASIL17AHumanNativeCHO CellsActive
51065-MNAEIL17AMouseNativeE. coli CellsActive
65006-T07BIL17ARabbitN-HisInsect CellsActive
65006-TNAEIL17ARabbitNativeE. coli CellsActive
70102-DNAEIL17ACanineNativeE. coli CellsActive
90287-CNAEIL17AMarmosetNativeE. coli CellsActive
90306-KNABIL17ARhesusNativeInsect CellsActive
90880-CNABIL17ACynomolgusNativeInsect Cells
CT047-H08HIL17A & IL17FHumanC-HisHEK293 CellsActive
CT047-HNAEIL17A & IL17FHumanNativeE. coli CellsActive
CT063-K08HIL17A & IL17FRhesusC-HisHEK293 Cells

Ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells in the presence of TNFα

Binding ability tested by ELISA

Recombinant IL17 receptors

IL17RAIL17RBIL17RCIL17RD

Other related proteins

IL17BIL17CIL17DIL17E/IL25IL17F

Antibodies for IL17 cytokines and receptors

Sino Biological has developed a comprehensive panel of antibodies targeting IL17 cytokines and receptors, which can be used in ELISA, WB, FCM, Neutralization, IP, and IHC. Matched ELISA antibody pairs are also available.

IL17: A driver of autoimmune disease and inflammation

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