8 June 2015

MAPK pathway

Wide range of antibodies specific for MAPK targets that have been validated for use in various applications.


ERK pathway

The extracellular signal-regulated kinase (ERK) pathway represents one of four mammalian mitogen-activated protein kinase (MAPK) systems responsible for reacting to various extracellular stimuli. While at least two of the other pathways respond primarily to various extracellular stress signals, ERK activation is predominately triggered by growth factors. These extracellular signals are transduced largely by tyrosine kinase receptor complexes that subsequently stimulate Ras to activate Raf, leading to MEK1/2 and then ERK1/2 activity. The ERK pathway is crucial for normal cellular proliferation, differentiation, and survival, with abnormal stimulation linked to human carcinogenesis.

Key ERK targets

BIMMAP2K1MKNK1RPS6KA5
B-RafMAP2K2MNK1STAT1
C-RafMAPK1MosStathmin 1
ELK1MAPK3MSK1Synapsin
ERK1MEK1p44/42 MAPK
ERK2MEK2RAF1

JNK pathway

The c-Jun-N-terminal kinase (JNK) pathway is one of four major mitogen-activated protein kinase (MAPK) pathways in mammals. Receptor-initiated signals generated by cell exposure to stress, cytokines, pathogens, toxins, or drugs activate the JNK pathway through MAP4Ks and the three-Ievel (MAP3K / MAP2K / MAPK) kinase backbone that culminates in activation of the MAPK JNKs. Activated JNKs target at least 50 substrates including transcription factors and mitochondrial proteins Regulation of these substrates by the JNKs directly impacts pivotal cellular processes involving cell fate, inflammation, metabolism, and carcinogenesis.

Key JNK targets

ATF2JNK3MAPK8MKK7
c-JunMAP2K4MEK4MLK1
ELK1MAP3K1MEK7MLK2
HGKMAP3K11MEKK1MLK3
HPK1MAP4K1MEKK2SEK1
JNK1MAP4K4MEKK3STAT3
JNK2MAPK10MKK4

p38 MAPK pathway

The p38 MAPK pathway is one of four MAPK systems in mammals that mediate cellular responses to external stimuli including stress and cytokines, among many others. The p38 MAPKs (α, β, γ, and δ), which are situated at the end of the canonical three-tier kinase cascade that is characteristic of these MAPK pathways, are intimately involved in fundamental cellular processes such as proliferation, differentiation, apoptosis, and metabolism. They also appear to be central players in many clinically important conditions, including autoimmunity, neurodegenerative disease, and cardiac ischemia.

Key p38 MAPK targets

ASK1MAP3K7MKK3STAT1
ATF2MAPK11MKK6TAK1 / MAP3K7
JIKMAPK12MSK1TAOK1
MAP2K3MAPK14p38TAOK2
MAP2K6MEK3P38 MAPKTAOK3
MAP3K5MEK6p53TP53
MAP3K6MEKK4RPS6KA5

ERK5 pathway & other MAPK family members

ERK3MAP3K14MAP4K6MEKK8
Erk3/MAPK6MAP3K15MAPK15MINK
MAP2K5MAP3K8MAPK4MINK1
MAP3K12MAP4K5MEK5

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