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Custom VLP Membrane Protein Expression Service
Sino Biological’s novel virus-like-particle (VLP) membrane protein expression technology
15 July 2025
KRAS mutant (G12D) Myc-DDK tagged human recombinant protein 
Tagged and Tag free GALT human recombinant protein
OriGene’s Custom Protein Services: Made in the US
OriGene’s custom protein services offer tailored solutions for every research need, from gene cloning to protein purification.
With over 25 years of experience, OriGene offers comprehensive custom protein services to accelerate your research, whether you’re targeting a novel protein or need a customized solution from our collection of over 19,000 recombinant proteins. As a trusted partner in end-to-end protein development, our capabilities span the full workflow—from gene cloning and protein expression to high-quality protein purification. We specialize in expressing challenging targets and offer flexible expression systems tailored to your specific project needs, supporting both basic research and therapeutic discovery.
Features
- Success Stories: 2,000+ projects | 500+ satisfied customers
- Multiplex Expression Systems: Choose from mammalian (HEK293T or CHO) and bacterial (E. coli) expression systems
- Scalable: Whether the need is small or large, we offer protein services from μg to gm levels
- Tag Customization: Customize your protein based on your application – Tag-free or add N- or C-fusion tags
- Site-specific Biotinylation: Modify your protein of interest with site-specific biotinylation using birA.
- Additional Customization: We offer additional customizations, including mutant protein expression, buffer customization, SEC purification, and more.
- Transparent pricing: Invoiced only for the successful completion of milestones
- Made in the USA: Our custom proteins are proudly manufactured here in Rockville, Maryland
Case Studies
1. Expression Systems
2. Site-specific Biotinylation
SDS-PAGE and Western verified site-specific biotinylated PKP2 human recombinant protein
Mono-biotinylated via Avi-tag
Biotin to protein ratio of 1:1 as determined by streptavidin pull down assay
3. Custom Modification
Available Custom Recombinant Protein Expression Systems
Mammalian Expression System
| Common Applications | Advantages | Challenges |
|---|---|---|
| • Functional and structural analysis • Antibody production • Protein interactions • Production of enzyme in large scale • Virus production | • Most authentic human protein products • Best preservation of native structure, function, and post-translational modifications • Create stable production cell lines for scalable solutions | • Complex culture conditions • Costly set-up and maintenance • Low yields • Scaling difficulties |
Insect Expression System
| Common Applications | Advantages | Challenges |
|---|---|---|
| • Functional and structural analysis • Expression of protein complexes • Expression of intracellular proteins • Virus-like particles production | • Post-translation modifications profile is similar to mammalian cells • Effective protein folding • More scalable than mammalian cells | • Virus production can be time consuming • Tricky to culture • Infection can induce premature lysis |
Bacterial Expression System
| Common Applications | Advantages | Challenges |
|---|---|---|
| • Structural analysis • Antibody production • Protein interactions • Enzyme production • Vaccine development | • Simple vector construction • Straightforward culture methods • High yields • Amenable to scaling | • No post-translation modifications • Improperly folded product • Susceptible to aggregation • Potential endotoxin contamination |
Interested in Custom Protein Expression Solutions?
For more information about Origene’s custom recombinant protein expression systems, please contact one of our account managers.
